Effects of Follicle-Stimulating Hormone Administration on Oestradiol-Induced Cystic Ovaries in Guinea Pigs

概要

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A consistent defect in follicle-stimulating hormone (FSH) secretion is seen in humans with Polycystic Ovarian Syndrome (PCOS); therefore, we evaluated whether Metrodin (a highly purified urinary FSH) administration concurrent with cyst induction or following cyst induction inhibits estrogen-induced cyst development and augments ovarian follicular growth in an established guinea pig model. All animals in these studies received subcutaneous implants containing oestradiol-17β (E_2)-filled Silastic capsules for a 48-hour period. Guinea pigs in study #1 were administered four O.25 ml injections of FSH or placebo at twelve-hour intervals simultaneously with the E_2 treatment; guinea pigs assigned to study #2 were administered four 0.25 ml injections of FSH or placebo at twelve-hour intervals following the induction of the cystic condition by E_2. Exogenous FSH appears to negate cyst formation when superimposed upon the cyst-inducing agent (E_2). Further, treatment with FSH augmented the number of mid-sized follicles in both paradigms. This study is the first to establish evidence of an anti-cystic effect of FSH in an animal model.
社団法人日本動物学会の論文
1996-02-15