Short-Term Hormone Release from Adult Female Rat Hypothalamic and Pituitary Explants is not Altered by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
スポンサーリンク
概要
- 論文の詳細を見る
TCDD has adverse effects on reproduction, in part due to direct actions at the ovary. It is unclear whether effects are further mediated by glands that regulate ovarian function. We investigated whether effects of TCDD are mediated via the hypothalamic-pituitary axis. Hypothalamic and pituitary tissues were cultured in medium with and without TCDD. TCDD did not alter GnRH release from hypothalamic samples. It continued to be pulsatile with no differences in the average peak frequency, average peak amplitude, or baseline GnRH release. TCDD did not alter GnRH-induced release of gonadotropins from pituitary samples. There were no differences in average peak amplitude or baseline release. AhR, ARNT or ER? mRNA copy numbers in cultured pituitaries were not affected by TCDD. Our data suggest that TCDD effects on ovarian function are not mediated through the hypothalamic or pituitary release parameters tested in this study.
- 日本繁殖生物学会の論文
- 2007-08-01
著者
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Hutz Reinhold
米国
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Trewin Amanda
Department Of Biological Sciences University Of Wisconsin-milwaukee
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Trewin Amanda
Department Of Biology University Of Wisconsin-platteville
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Hutz Reinhold
Department Of Biological Sciences Niehs Marine And Freshwater Biomedical Sciences Center University
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Brown Wimpee
Department Of Biological Sciences University Of Wisconsin-milwaukee
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Woller Michael
Department Of Biological Sciences University Of Wisconsin-whitewater
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CONLEY Lisa
Department of Biological Sciences, University of Wisconsin-Milwaukee
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BALDRIDGE Monika
Department of Biological Sciences, University of Wisconsin-Milwaukee
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Conley Lisa
Department Of Biological Sciences University Of Wisconsin-milwaukee
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Baldridge Monika
Department Of Biological Sciences University Of Wisconsin-milwaukee
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Hutz Reinhold
Niehs Children's Environmental Health Sciences Core Center Univ. Of Wisconsin-milwaukee
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Wimpee Barbara
Department of Biological Sciences, University of Wisconsin-Milwaukee
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