Effects of Gonadotropin-Specific Antibodies on the Interaction of Follicle-Stimulating Hormone and Luteinizing Hormone with Testicular Receptors in the Bullfrog, Rana catesbeiana : Endocrinology
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概要
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TO Study the properties of the receptor-binding site in molecules of bullfrog gonadotropins, we treated follicle-stimulating hormone (fFSH) and luteinizing hormone (fLH) from the bullfrog with antibodies raised against the whole molecules or subunits of these hormones , and then examined the binding of the treated hormones to bullfrog testicular receptors. When low concentrations of fFSH-specific and fLH-specific antisera were used , increased concentrations of the antisera led to increased inhibition of binding of both hormones. At higher concentrations, however, the extent of binding was elevated by the antisera in both cases. These stimulatory effects were abolished by treatment of antisera with papain, while the inhibitory effects persisted. Binding of fFSH to its receptors was inhibited by a monoclonal antibody against fFSH-β and by one against fFSH-α but not by a monoclonal antibody against fLH-β. The inhibitory potency of the antibody against fFSH-αwas stronger than that of the antibody against fFSH-β. Binding of fLH was inhibited by the monoclonal antibody against fFSH-βmore strongly than by one against fFSH-α. Binding of fLH was not inhibited or slightly inhibited by the monoclonal antibody against fLH-β. These results suggest that both theαand β subunits contribute to the binding of both hormones to their receptors. Although fFSH and fLH bind to a common receptor in the bullfrog testis , the chemical structures of the receptor-binding sites in these hormones are assumed not to be identical. The importance of the a subunit in the binding of fFSH to receptors is also suggested.
- 社団法人日本動物学会の論文
- 1990-08-15
著者
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Ishii Susumu
Department Of Biology School Of Education Waseda University
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Yamanouchi Hiroshi
Department Of Biology School Of Education Waseda University
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Ishii Susumu
Department of Biological Science, Graduate School of Science, Tokyo Metropolitan University
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