膠原病とアフェレシス : 皮膚筋炎(DFPP) : 皮膚筋炎に対する血漿交換療法(DFPP)の試み

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We report three cases of "steroid-resistant" dermatomyositis successsfully treated with double-filtration plasmapheresis. The patients were admitted to our university hospital complaining chiefly of skin eruptions and muscle weakness and pain. The prescribed drugs proved to be slightly effective initially. Because no further improvements were noted in the three cases, however, they were considered to be unresponsive to treatnment and instead, double-filtration plasmapheresis (DFPP) therapy was applied, a kind of treatment using the DFPP system (Kuraray, Osaka, Japan).After 9 to 20 treatments, the patients' conditions showed dramatic improvement. The skin eruptions, muscle weakness, and pain were alleviated, and serum levels of muscle-derived enzymes (CPK, GOT, GPT, and ALD) and the titers of ANA and anti-DNA gradually decreased as a result of this treatment. The steroid dosage was successfully decreased during and after DFPP therapy. Remission has continued to the present. These results suggest that DFPP therapy is effective even for steroid-resistant dermatomyositis.
2000-10-31