活動期潰瘍性大腸炎に対する顆粒球吸着療法の有効性について : ビーズを用いた白血球系細胞除去療法

概要

論文の詳細を見る
Twelve patients with active ulcerative colitis were treated with granulocyte and monocyte apheresis with G-1 column, undergoing a total of 5 apheresis, each of one-hour duration, over 5 weeks. At the end of the treatment course, the clinical usefulness of G-1 column was determined to be 66.7%, and only 2 cases had a headache side effect. On comparing the patients who achieved remission with the patients who did not, it was thought to be important to start granulocyte and monocyte apheresis with G-1 column as soon as possible after the disease relapsing. Although there was no difference in clinical background, laboratory data, or immunological parameters between the patients having achieved remission and the patients who did not, patients whose colonoscopy found deep ulcers surrounded with pseudopolyposis were thought to be hardly achieved remission. The ultimate usefulness of this therapy for a given patient can be predicted well by assessing the ulcerative colitis activity index after just 2 apheresis performed with G-1 column. This clinical study suggests that the G-1 column apheresis system is a safe and very effective therapy for patients with active ulcerative colitis.
日本アフェレシス学会の論文
2000-02-29