潰瘍性大腸炎に対する遠心分離式白血球除去療法の治療効果の解析 : 遠心分離法を用いた白血球系細胞除去療法

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We have found that centrifugal leukocytapheresis (CFLA) induces remission on corticosteroid-insensitive patients with active ulcerative colitis (UC). In this study, we extended the analysis indication. Fifty-one of the response, efficacy, and limitation of this CFLA to elucidate in this study. All these patients failed to respond to conventional corticosteroid treatments. CFLA was performed once a week for 4 weeks. The cumulative remission-inducing efficacy (determined by a slinical activity index : CAI≤4) of CFLA in each session was 15.7% (1 week), 41.2% (2 weeks), 60.8% (3 weeks), and 62.7% (4 weeks). The logistic regression analyses of patients' characteristics showed no significant association between a successful result of CFLA and disease extent, disease duration, or life-total amount of corticosteroid administered. CFLA was more effective in patients with doderated active disease (initial CAI <10,24/30 [80%]) than those with severe disease (initial CAI ≥11,2/8 [25%]). Our protocol of CFLA may provide another alternative therapy for corticosteroid-insensitive active UC patients. This result encourages us to arrange furhter prospective study of CFLA.
日本アフェレシス学会の論文
2000-02-29