多発性硬化症とアフェレシス(<特集>免疫性神経疾患とアフェレシス,新しい展望)

概要

論文の詳細を見る
Therapeutic apheresis is divided into cytapheresis and plasmapheresis. Plasmapheresis (PP) is further divided into three treatments : plasma exchange (PE), double filtration plasmapheresis (DFPP) and immunoadsorption plasmapheresis (IAPP). PE has been applied in neruoimmunological disorders and the effectiveness of PP has been well established in some neuroimmunological disorders. In this article, PP treatment of multiple sclerosis (MS) is reviewed. PP is an effective means of removing the pathogenic immune-mediated factors, such as inflammatory cytokines, autoantibodies, immune complexes, and complements. PP may affect not only humoral immune responses but also cellular immune responses. We report that PP suppressed Th 1 immune responses and enhanced Th 2 immune responses. Previous clinical reports of MS suggested that PE might be effective in treating acute attacks of relapsing-remitting MS, but be of no effect in patients with chronic progressive MS. IAPP may be superior to PE in the treatment of MS.
日本アフェレシス学会の論文
2004-10-31