COMPARATIVE STUDIES BETWEEN HORMONE CONTENTS AND MORPHOLOGICAL APPEARANCES IN HUMAN ADRENAL CORTEX
スポンサーリンク
概要
- 論文の詳細を見る
The hormone content in Cushing-type non-functioning tumors of the adrenal glands was measured to be compared with those of functioning adenomas. Furthermore, the relationship between the hormone contents and the proportion of clear-type cells and compact-type cells in the tissues were also studied. The contents of aldosterone and corticosterone were significantly higher in primary aldosteronism than in other groups. The cortisol content was significantly higher in Cushing's syndrome than in primary aldosteronism, but it was not statistically different from non-functioning adenomatous nodules. The patterns of hormone contents in non-functioning adenomatous nodules were similar to those in Cushing's syndrome. In primary aldosteronism, there was a positive correlation between the aldosterone content and the increase of compact-type cells. Compact-type cells revealed high activities of 3β-hydroxysteroid dehydrogenase and glucose 6-phosphate dehydrogenase. These results suggest that compact-type cells play an important role in synthesis and secretion of aldosterone in primary aldosteronism. In Cushing's syndrome, there was no significant correlation between the cortisol content and the proportion of constituting cells. The activities of 3βHSD and G6PD in both types of cells were not so different from each other. Therefore, there may be a possibility that morphological differences in the two types of constituting cells show different phases of tumor cells in Cushing's syndrome. In the non-functioning tumors, the scattered tumor cells revealed marked activities of 3βHSD and G6PD. These results suggest that the number of constituting cells of “non-functioning” tumors have some degree of endocrinologic activity.
- 日本組織細胞化学会の論文
著者
-
Shigematsu Kazuto
Department Of Pathology 2 Nagasaki University
-
Shigematsu Kazuto
Department Of Pathology Nagasaki University School Of Medicine
関連論文
- Systemic Effects of Carteolol, a β-Adrenoceptor Antagonist in Stroke-Prone Spontaneously Hypertensive Rats
- Angiotensin II and Alpha-human Atrial Natriuretic Polypeptide Binding Sites in the Human Adrenal Gland
- Combined adrenal adenoma and myelolipoma in a patient with Cushing's syndrome : Case report and review of the literature
- Adrenocorticotropic hormone-independent bilateral macronodular adrenocortical hyperplasia associated with Cushing's syndrome
- Histochemical Study of Endocrine Cells in Adenocarcinomas of the Glandular Stomach and Small Intestine of Rats induced by Carcinogens
- Comparative Studies of Corticosteroid Content between Non-functioning Adenomatous Hyperplasia and Functioning Adenoma
- Partial Characterization of IGF-I in Primary Human Lung cancers
- THE PROCEDURE FOR ULTRACYTOCHEMICAL DEMONSTRATION OF DEHYDROGENASES IN THE RAT ADRENAL CORTEX USING COPPER FERROCYANIDE
- Role of Connective Tissue Growth Factor and Angiotensin II in Tubulointerstitial Fibrosis in Experimental Obstructive Nephropathy
- COMPARATIVE STUDIES BETWEEN HORMONE CONTENTS AND MORPHOLOGICAL APPEARANCES IN HUMAN ADRENAL CORTEX
- Effects of MPC-1304, a Novel Calcium Antagonist, on Stroke-Prone Spontaneously Hypertensive Rats
- Expression of the Endothelin Receptors in the Hippocampus of SHRSP after Transient Forebrain Ischemia
- Evaluation of the neuroprotective action of WEB 1881 FU on hypoglycemia/hypoxia-induced neuronal damage using rat striatal slices.
- Localization and Characterization of Specific 125I-Brain Natriuretic Peptide (26) Binding Sites in Adrenal Gland and Kidney
- Antihypertensive effects of CD-349, a novel 1, 4-dihydropyridine derivative on stroke-prone spontaneously hypertensive rats
- Endothelin (ET) receptor binding sites and expression of ET mRNAs in the rat lower brainstem