HISTOCHEMICAL STUDIES ON STEROID 3β-ol DEHYDROGENASE IN SOME TRANSPLANTABLE TUMORS OF MICE : THE ACTIVITIES OF TUMOR TISSUES

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The activity of steroid 3β-ol dehydrogenase (steroid 3β-ol DH) was studied enzyme-histochemically using the following transplantable tumors of mice which had been kept in our laboratory. Gardner's 107 testicular interstitial cell tumor and the transplantble granulosa cell tumor, originated from the steroid hormone-producing cells, always showed a positive activity of the enzyme. It revealed that the former still retains the enzyme activity even to the present time, despite of serial transplantations in over ten years. The enzyme activities of the transplantable pulmonary tumors showed a wide range from highly positive to negative. The fact that some of them showed a highly positive reaction, in relation to hyperestrogenism found in the hosts at the stage when the tumors became histologically anaplastic,was an especially interesting finding. The enzyme activity was also positive in some transplantable liver cell tumors. The enzyme activity was completely negative in the osteosarcomas(519OS and AKR/MSOS).
日本組織細胞化学会の論文