THE EFFECT OF 5-AND 6-HYDROXYDOPAMINE ON THE CENTRAL MONOAMINERGIC NEURONS OF THE RAT AND THE CAT : FLUORESCENCE HISTOCHEMISTRY AND ELECTRON MICROSCOPY
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概要
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The influence of 5-hydroxydopamine (5-OHDA) and 6-hydroxydopamine (6-OHDA) upon the aminergic neurons of the central nervous system was investigated by fluorescence histochemistry and electron microscopy using the neostriatum, the hypothalamus, including the median eminence, and the substantia nigra of albino rats and cats. After the administration of 5-OHDA into the lateral ventricle or third ventricle, aminergic terminals containing small dense-cored vesicles (400-600 Å in diameter) and large cored vesicles (700-1,000 Å in diameter) appeared in the structures listed above. A number of dense-cored vesicles (600-800 Å in diameter) were found in the perikarya of some nerve cells of the substantia nigra after treatment with 5-OHDA. It was established that 5-OHDA can be utilized as a marker of both central noradrenaline and dopamine neurons and that endogenous amines are stored in the small vesicles as well as in the large densecored veiscles. On the other hand, intensive depletion of both noradrenaline and dopamine fluorescence occurred in all regions except the external layer of the median eminence after treatment with 6-OHDA. The nerve cell bodies of the substantia nigra, containing dopamine in their perikarya, were less affected by 6-OHDA than the terminals. The administration of 6-OHDA in excess of 500 μg produced degeneration of aminergic terminals in animals surviving more than 2 days. However, for short survival times of 1 hr, we observed terminals containing small dense cored vesicles similar to those seen after administration of 5-OHDA. A marked depletion of amine fluorescence without ultrastructural damage was also observed in the aminergic terminals.
- 日本組織細胞化学会の論文
著者
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Sano Y
Department Of Appilied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Nojyo Y
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Matsuura T
Department Of Anatomy Meiji University Of Oriental Medicine
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Inoue T
Department Of Agricultural Engineering Faculty Of Agriculture Hokkaido University
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IBATA Y
Department of Anatomy, Kyoto Prefectural University of Medicine
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Ibata Y
Department Of Anatomy Kyoto Prefectural University Of Medicine
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