Structure-Function Relationship in the Normal and Malignant Ovary during Programmed Cell Death (Symposium IRegulation of Endocrine Function)

概要

論文の詳細を見る
Ovarian cell death is an essential process for the homeostasis of ovarian function in humans and in other mammalian species. It ensures the selection of dominant follicle and the demise of an excessive number of follicles. Degeneration of the old corpora lutea also has a characteristic of programmed cell death. Cross-talk between endocrine, paracrine and autocrine factors as well as between protooncogenes, tumor-suppressor genes, survival genes and death genes can determine the fate of the ovarian somatic and germ cells. Establishment of highly transformed human and rat granulosa cells enables detailed studies on the role of the p53 tumor suppressor gene, cyclic AMP (cAMP), growth factors and extracellular matrices in controlling growth and apoptosis in experimental ovarian cells. It is hoped that stimulation of apoptosis in ovarian cancer cells will become one of the strategies in the treatment of ovarian cancer.
日本組織細胞化学会の論文