Differential Distribution of Glycosphingolipid Antigens in the Central Nervous System (<Symposium I>Recent Progresses in Carbohydrate Histochemistry)

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概要

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• We established an improved method for the generation of mouse monoclonal antibodies (MAbs) to glycosphingolipids especially gangliosides, sialic acid-containing glycosphingolipids, by immunizing mice with purified gangliosides. Using this method, we generated and characterized a large number of the MAbs specific for gangliosides. These MAbs enabled us to examine the distribution of gangliosides in the brain. Immunohistochemical studies revealed that (i) the expression of each ganglioside is restricted to subsets of neurnal cells and their surrouding neuropils in the central nervous system of the adult rat, including cerebrum, cerebellum, hippocampus, and spinal cord, and (ii) the expression of gangliosides changes during the development. Immunocytochemical studies also revealed a cell type-specific expression of gangliosides in primary cultures of the rat cerebellum. These results suggest that the specific gangliosides may play important roles in various phenomena, involving cell-cell recognition, neurite outgrowth, synaptogenesis, transmembrane signalling, apoptosis, and cell growth and differentation in the central nervous system.

• 日本組織細胞化学会の論文

著者

• Kawashima I

  東京都医学研究機構東京都臨床医学総合研究所 がん･生活習慣病プロジェクト

• Kawashima Ikuo

  Department Of Clinical Genetics The Tokyo Metropolitan Institute Of Medical Science Tokyo Metropolit

• Tai Tadashi

  Department Of Tumor Immunology And Clinical Genetics Tokyo Metropolitan Institute Of Medical Science

• Tai T

  Departments Of Tumor Immunology

• Kotani Masaharu

  Department Of Clinical Genetics The Tokyo Metropolitan Institute Of Medical Science Tokyo Metropolit

• Kotani M

  Department Of Tumor Immunology The Tokyo Metropolitan Institute Of Medical Science

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