フィブリノゲンと動脈硬化(<特集>老化とアフェレシス)

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This study reports an association between increased fibrinogen levels and early signs of atherosclerosis in asymptomatic individuals. Also, increased fibrinogen levels have been identified as an important risk factor for future cardiovascular symptoms in several prospective long-term studies of apparent healthy individuals and patients with stable coronary or cerebral artery diseases. Fibrinogen acts as an acute-phase protein and increases after a stroke. Increased levels of fibrinogen are associated with mortality after myocardial infarction, and found in patients with unstable angina and peripheral vascular diseases. A strong correlation between fibrinogen and C-reactive protein (CRP), another inflammatory marker which has been shown to predict atherosclerosis and coronary artery diseases, was found in numerous studies. Interleukin 6 (IL-6), an activation marker of chronic inflammation, is a key regulator of the acute-phase response and stimulates the expression of fibrinogen, CRP, serum amyloid A protein and angiotensinogen in the liver. This, in turn, activates the coagulation pathway, renin angiotensin system, or the lipid or lipoprotein oxidation. leading to atherosclerosis. Some polymorphisms in β-fibrinogen genes elevated the fibrinogen levels also associated with the risk of atherosclerotic diseases. Elevated inflammation and coagulation markers may potentiate the atherogenesis of hyperlipoproteinemia.
日本アフェレシス学会の論文
2004-05-31

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