末梢動脈疾患とアフェレシス(<特集>血管病変とアフェレシス)

概要

論文の詳細を見る
In patients with peripheral arterial disease (PAD) having poor indications for operations such as bypass surgery, impaired peripheral circulation is improved with low-density lipoprotein apheresis (LDLA) treatment. Suppression of oxidative stress and improvement of endothelial functions may occur with improvement of the rheological property of blood as a result of aggressive removal of atherogenic factors including LDL, possibly suppressing the development of atherosclerosis. Atherosclerosis is more extensive and progressive in patients receiving maintenance dialysis than in patients with normal renal function because of the presence of pathogenesis including a potential microcirculatory disturbance, which is peculiar to dialysis patients. There could be many dialysis patients for which operations for PAD are considerably difficult by the time of diagnosis. Furthermore, some patients also have blood access-associated steal syndrome, an arterial disease of the upper extremities. LDLA may become an important and more effective therapy.
日本アフェレシス学会の論文
2003-05-31