「上部尿路通過障碍腎の電子顕微鏡学的研究」 : 第1編: 実験的水腎における糸球体の変化について

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Morphologic changes of the glomerulus of experimental hydronephrosis in the male Wister rats produced by complete mechanical obstruction of the right ureter were studied by electron-microscopy. The results are summarized as follows : 1) Capillary basement membrane of the normal rats glomeruls is about 500 to 800 A in thickness, endothelial pore is about 300 A in diameter, and the basement membrane of Bowman's capsule is about 800 to 1100 A in thickness. 2) Electron-microscopic changes of the glomerulus began about 2 weeks after ligation and these became marked in 3 or 4 weeks in general. 3) Changes in glomerular epithelial cells : Proliferation and swelling were observed 2 weeks after and reached maximum about a month after. Cells became flatter 2 or 2.5 months after, degenerated and became fibrous at last. 4) Changes in glomerular endothelial cells : Changes began slowly and were very little. Only disappearance of endothelial pore and flattening of cells were observed 2 months after. 5) Changes in capillary basement membrane : Thickening and proliferation of basement membrane-like materials were observed 2 weeks after and these became marked in a month. After 4 months, when all other components turned into collagen fiber, the basement membrane remained unchanged. (I defined thickness over 1000 A as thickening.) 6) Changes of mesangium : The mesangium was well preserved for a fairly long time and proliferation remained very little to the last. 7) Changes of Bowman's capsule : Thickening and winding of the basement membrane of Bowman's capsule and proliferation and swelling of epithelial cells were observed 3 weeks after. The thickening reached its maximum and then-gradually degeneration advanced.
社団法人日本泌尿器科学会の論文
1968-11-20

「上部尿路通過障碍腎の電子顕微鏡学的研究」 : 第1編: 実験的水腎における糸球体の変化について

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