泌尿器科領域における放射性同位元素の応用 : 第3報放射性同位元素による膀胱癌の後腹膜リンパ節転移巣の治療に関する実験的並びに臨床的研究

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The author applied the Y^<90> colloid and Cs^<137> needle as an interstitial and bracky therapy to eradicate the metastatic retroperitoneal lymphnodes in bladder cancer. 1) The amount of Y^<90> colloid distributed to the regional lymphnodes is at most 1〜2μc per gr. tissue, when the colloid is injected into the dog's bladder wall. This amount is far below the theoretical tumor lethal dose. 2) The maximum amount of Y^<90> colloid distributed in the regional lymphnodes is 12 μc per gr. tissue, when the colloid is sprinkled into the dog's retroperitoneal space. 3) When the colloid is injected directly into the nodes the maximum amount attains to several hundred μc per gr. tissue. The more the amount of colloid, the higher the grade of destruction of lymphnodes. This method was applied to nine patients without any complications. 4) Bracky therapy with Cs^<137> needles produces remarkable degeneration of the nodes, when the administered dose exceeds 3000r. Six patients were treated by Cs^<137> needl bracky therapy. No serious complications were noticed.
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