膀胱の感染防御機構の研究 : 細菌の膀胱上皮内侵入過程の電顕像

概要

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E. coli was inoculated into rat bladder. After several periods of free voiding, the bladder was observed with a transmission electron microscope. Further, a silicone tube was introduced to the bladder with bacterial suspension, and the effect of the foreign body on cystitis was observed. As a first step, the bacteria were attached to the luminal membrane. Then, the luminal membrane became infolded to envelope the bacteria and to take them within the cytoplasm. The unit membrane surrounding the bacteria were destroyed later and some of these bacteria were found to be deformed or multiplicated within the cytoplasm. Finaly, the infected epithelial cells were collapsed and desquamated, which were washed out with bacteria. Within 24 hrs after bacterial inoculation, epithelium showed complete recovery forming normal three layers.
社団法人日本泌尿器科学会の論文