泌尿***悪性腫瘍の肺転移に関する研究 : (2) X線学的検討 : 転移巣の増殖曲線について

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1) Roentgogenological analysis of nodular type metastasis in lung, from urogental malignant tumors, was made on 17 untreated cases. The results were as follows: i) The growth curves of pulmonary metastases in semilogarithmic chart were almost linear. Therefore, pulmonary metastases were considered as logarithmic growing. ii) Several pulmonary metastases in one patient were growing at the almost same rate. iii) The growth rate of pulmonary metastasis was dependent on the characteristic of the original tumor. a) Super rapid or rapid growing group: The doubling times of Wilms tumor, testicular tumor and prostatic sarcoma were from several hours to 30 days. b) The intermediate growing group: The doubling times of renal cell carcinoma, renal pelvic and bladder cancer were from 30 days to 60 days. c) The slow growing group: The doubling times of 1 case of renal cell carcinoma and 2 cases bladder cancer were from 60 days to 120 days. d) The very slow growing group: The doubling times of 1 case of bladder cancer was over 120 days. iv) The establishing time of the pulmonary metastases was calculated from their growth rates. In 12 cases, the pulmonary metastases were established before the manifestation of their first clinical symptoms of primary tumors. And in 3 cases, the metastases originated about the manifestation of their first clinical symptoms but before the surgical procedure. In only 2 cases, the metastases were disseminated after their surgical procedure. v) In three cases of renal pelvic and bladder cancer, the doubling times were more than 70 days, which meant the necessity of more than 5 years observation to find the metastasis. 2) The changes of the growth curves of pulmonary metastases caused by treatment (radiation therapy, chemotherapy and hormone therapy) were analyzed on 5 cases of urogenital malignant tumors. It was reveled that the changes of growth rates of pulmonary metastases were well correlated with the effects of each treatment. Therefore, it was concluded that the analysis of alternations of growth rate in pulmonary metastases is important for evaluation of their treatment.
社団法人日本泌尿器科学会の論文

泌尿***悪性腫瘍の肺転移に関する研究 : (2) X線学的検討 : 転移巣の増殖曲線について

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