腎細胞癌の内分泌療法に関する基礎的研究 : 正常および腎細胞癌組織内における estrogen receptor について

概要

論文の詳細を見る
On the basis of experimentally induced renal cancer by estrogen in the hamster, it is suggested that human renal cell carcinomas are also hormone-dependent. Endocrine therapy for this tumor is proposed clinically, and it is recognized that some of the patients responded to a certain degree to this treatment. At present, however, there is no knowledge about what kind of tumor is hormone-dependent. To solve this question, estrogen receptor (ER) was sought in the cytosol from 25 renal cell carcinoma tissues and 8 normal kidney tissues. Specific binding molecules to estradiol detected by means or dextran coated charcoal assay were determined 7-8 sedimentation constants by sucrose density gradient centrifugation. The ability of this binding were not inhibited competitively by testosterone or dihydrotestosterone. For these reasons, it was confirmed that the specific binding protein was not a sex hormone binding globulin (SHBG) but ER.
社団法人日本泌尿器科学会の論文