実験的膀胱腫瘍に関する研究 : 特に担癌生体の細胞性免疫能について

概要

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Experimental bladder tumors were induced in rats by oral administration of 0.025% BBN and investigations were performed concerning histopathological changes in the bladder with respect to tumorigenesis and changes with time in the mitogen response of lymphocytcs of rats treated with carcinogen. There were no significant differences in body weight changes between the experimental and control groups. There was a remarkable increase in bladder weight in the experimental group, while the thymus weight showed a significant drop (p<0.01). From about 12 weeks after BBN administration, hyperplasia started in the bladder mucous epithelium, there was a gradual growth in a papillary form and after 24 weeks, transitional cell carcinomas were found in all rats. The SI values of the lymphocytes from cervical and mesentric lymph nodes began to decrease significantly (p<0.05) from the time hematuria was observed macroscopically (about 21 weeks after BBN treatment) but there were no significant differences between additions of PHA and Con A. The SI values of the lymphocytes from the thymus showed significant decreases (p<0.01) from the time hyperplasia was found in the bladder mucous membrane (about 15 weeks) before the significant reduction of mitogen responses of lymph node lymphocytes appeared. This decrease was much greater in the case of Con A stimulation than in the case of PHA.
社団法人日本泌尿器科学会の論文
1978-08-20