ヒト泌尿生殖器系悪性腫瘍の異種移殖に関する研究 : 第1報ヌードマウスへの移植実験およびヌードマウス可移植性ヒト前立腺癌に対する治療実験

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1. Twenty-nine human urogenital tumors were transplanted into athymic nude mice with the genetic background of BALB/c which were kept under the specific pathogen free condition. The results were as follows (Table 1): 1) The tumor take was confirmed in 12 of the neoplasms, which consisted of 2 (66%) of 3 renal cell carcinomas, 1 (50%) of 2 ureteral carcinomas, 8 (80%) of carcinomas of the urinary bladder and 1 (11%) of 9 testicular tumors. 2) Of these neoplasms, 7 serially transp1antable tumors were established, including 2 (100%) of the renal cell carcinomas and 5 (62.5%) of the carcinomas of the urinary bladder. 3) At present, the longest maintenance is in the 6th passage and the shortest in the 2nd passage, both being of the carcinomas of the urinary bladder. 4) No metastatic lesions were revealed in any of the nude mice transplanted with tumors.
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