水銀中毒の歯科学的研究 : 第 I 編水銀連続投与の歯牙並びに歯周組織に及ぼす影響に関する病理組織学的研究(後半)

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The author administered intramusclarly the various concentration of mercuric chloride solution to albino rats and caused experimentally mercury poisoning. The patho-histological findings of the teeth and the peridental tissues were clarified and the author obtained his opinion concerning the patho-histological nature and appearing mechanism. 1) Patho-histologically the soft tissues such as tooth germs, dental pulps, peridental membranes and dental gums showed as a rule the symptoms of atrophy, proliferation, hydropic cyst formation that were chronic type as well as the symptoms of degeneration, necrosis and circulatory disturbance that appeared highly in acute type. The patho-histological nature of the hard tissues such as enamel, dentine, cement and alveolus was calcification impediment, forming decrease of the ground substances and its formation anomaly in incisors, while in molars proliferation, abortion and fusion that are cardinal phases, and proliferation is recognized remarkably in chronic type. 2) Patho-histological changes of the enamel system. In enamel-forming anlages, turbidity and swelling of cells, hydropic degeneration proteinic degeneration, atrophy, necrobiosis and necrotic aspects were found, and the abnormal proliferation of the outer enamel cells, hydropic cyst formation of the intra-mediary layers and enamel pulps were recognized. In the calcifying layers of the enamel of incisors were often found out diffuse calcifying impediment, forming decrease of the ground substances, formation anomaly of prisms, wave form figure in the younger layer, enamel drop-forming, pile of abnormal substance, appearance of Retzius line. While in molars the frequent occurrence of dental caries was recognized. 3) Changes of the dentine In incisors the following findings were recognized, namely the forming decrease of the ground substances, cloud like dentine that was deemed diffuse calcification impediment, anomaly of dentinal tubules and fibres. While in molars there were observed disappearance of calcareous globes as decalcifying phenomenon, derangement of Andresens lines. caries-like change, crevice-forming, appearance of the fusing aspect starting from the pulp cavity wall, absorption, dentikel formation of the secondary dentine, hindrance or suspension of globe-shaped calcification in the praedentine both of incisors and of molars, increase or decrease of width, degeneration of proteinic line deposition and Tomes fibres. 4) Patho-histological changes of the dental pulp system. As the fundamental changes of the pulps of iucisors and dental papillae, the author found the degeneration and atrophy of odontoblasts, cells proper and Korffs fibres, hydropic degeneration of the ground substance, in the fatty degenration transformation into necrosis from hydropic cyst formation. While in molars atrophy, degeneration, partial necrosis and corruption of odontoblasts and cells proper, calcification of the ground substance, in the circulatory system hyperaemic dilatation of fine vessels, vessel leakage, collapse haemorrhage, erythro-thrombus formation. 5) Changes of the cement. As the main patho-histological changes of the incisors cementum, the forming decrease of the ground substance calcification impediment, hydropic cyst formation of cementblasts were recognized. While in molars proliferation, absorption, fusion, dentikel, occurrence of caries were recognized and cementblasts fell in atrophy, degeneration and necrosis. 6) Changes of the periodontal tissues. There were found commonly atrophy, hydropic degeneration, mucous degeneration necrosis, hydropic cyst formation and hyperaemic dilatation, anaemia, leakage collapse haemorrhage anb thrombus formation in the blood vessel system as the changes of the periodontium and dental capsule. 7) Changes of the alveolar bone. There were found the absorption of the ground substance, fusion, decalcification, proliferation in case of the degeneration of osteoblasts, fibrous and mucous changes of the marrow, cilculatory disturbance, degeneration and atrophy of osteoblasts. 8) Changes of the dental gum. In gum there were found progressive keratinization, hyperaemia, proliferation, degeneration, atrophy, necrosis, bistruction, corruption, decomposition in the lamina propria, cell infiltration, distinguishing circulatory disturbance of the blood vessel system and devastation of the ground substance. 9) The patho-histological findings of the reactions of the dental organ against mercury were different for different tissues. There were observed various amelioration and modification that were distinguished incisors from molars. Each pathological type showed grade transition and a certain characteristic was pointed out. Its patho-histological nature was rich in various phases. 10) In order to cause the reaction of the dental organ to mercury, mercury is the first factor. Successively circulatory disturbance occurred. inevitably in the local tissue is the second factor and this causes the third pathological changes in the soft tissues of the deutal organ. The pathological changes of the hard tissues are considered the 4th or 5th changes inducedl from such pathological changes of the soft tissue. That is to say, the pathological changes of the enamel, the author supposes, is the genuine incomplete formation of the enamel caused by the primary injury of the enamel anlage. The ones of the dentine are caused in succession of the pathological changes of the dental pulp, and the ones of the cment and alveolar bone are induced through the pathological changes of the periodontium.
九州歯科学会の論文
1955-11-30

著者

梶谷貫大
九州大学医学部衛生学教室

水銀中毒の歯科学的研究 : 第 I 編水銀連続投与の歯牙並びに歯周組織に及ぼす影響に関する病理組織学的研究(後半)

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