ヂランチン歯肉肥大症の実験的研究 : 第 I 編 ALEVIATIN 連続投与の臨床的観察

概要

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Under the intention to make the appearing mechanism of the so-called dilantin-hypertrophy of the gingivae clear, the author carried out the following experiment using 12 albino rats and 10 dogs that were in the stage of growth. Dosages of aleviatin : The dogs were administered through mouth 0.02∿0.1 g at aleviatin per kilogram continuously evryday, i. e. 0.52∿508 g for 15∿670 days. While the albino rats, 0.1∿0.3 g per kilogram every, i. e. 3.33∿42.6 g for 193∿312 days. General findings : The majority of the animals except few cases that died of ataxia, did not show any remarkable changes. Local findings : Slight swelling of the gingivae appeared widely in all experimental dogs in about a month of dilantinadministration and then disappeared gradually. The reasons that the dilantin-hypertrophy of the gum could not be caused experimentally in dogs and albino rats were probably due to different susceptibilities peculiar to each kind of animals to the drug and might be resulted in the differences of the drug actions within animals bodies. While, as local reasons there could be considered various living circumstances and morphological, functional and physiological varieties based on the differences of the anatomical structures of the parondontiums, especially of the gum peculiar to each kind of animals. Out of all, local conditions should be regarded to be most to this illness.
九州歯科学会の論文
1954-08-30