家兎歯肉癌(VX_2 癌)の上顎骨浸潤に関する実験的研究
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There are various forms of treatment for managing oral cancers which includes surgery, preoperative and postoperative radiotherapy, and chemotherapy. The oral cavity however is rather complex anatomically and histologically. Bacuase of complex morphology of the upper jaw, invasion and proliferation of carcinoma into the maxillary palate or sinus or to the deeper tissues are varied and not completely clarified. In order to find out whether there is any invasions and prolieration of carcinoma of the maxillary gingiva into the maxilla and maxillary sinus, VX_2 carcinoma was transplanted into the gingiva of the maxilla of domesticrabbits and the state of its invasion into the maxilla was investigated histopathologically and roentgenologically. The results were as follows : 1. The cells of VX_2 carcinoma transplanted into the maxillary gingiva of domestic rabbits formed small bulla first in the gingiva, which invaded incord-like form, and destroyed periosteum. The cortical bone surface showedlacuna type of resorption and bone destruction was seen in the form of moth-eaten appearence in certan areas. These findings increased in extent and degree with time as the VX_2 carcinoma mass enlarged. 2. Along with resorption and destruction of the cortical bone by VX_2 carcinoma, resorption of the inner wall surface and enlargement of canals were observed in the surrounding Harversian and Volkman canals. VX_2 carcinoma invaded and proliferated in some of the enlarged Haversian and Volkman canals from the cortical bone. Enlargement of Haversian and Volkman canals therefore was considered to make the invasion of VX_2 carcinoma easier. 3. On the opposite side, new bone formation was observed. Whether this formation was due to defense against tumors or to tumor-host relationship was not clear. 4. VX_2 carcinoma invaded the maxillary floor where resistance is comparatively low to the maxillary sinus, hypertrophy of the tunica mucosaof the maxillary sinus was seen and decidual columner epthelium and squamous epithelium were found in the psuedostratified ciliated columunar epithelium. Furthermore, VX_2 carcinoma rapidly enlarged along the tunica mocosa of the maxillary sinus. 5. Roentogenologically, VX_2 carcinoma was seen in the form of flat and smooth or irregular bone destruction of cortical bone, and the morphology of the maxillary sinus became indistinct. The degree and extent of destruction increased with time. Even though no abnormality of the cortical bone was seen roentgenologically, the cortical bone had already been resorbed histopathologically. 6. The forgoing experiment findings give suggestions as to the mode of invasion and proliferation of cancer of gingiva of the maxilla. The findings also provide grounds from which setting of surgical safety marginand selection of treatment method are made with due cosideration on invasion and proliferation of cancer of gingiva into the maxillary sinus.
- 九州歯科学会の論文
- 1993-06-25
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