Tetracycline 系抗生物質が乳歯におよぼす影響 : とくに着色歯の螢光顕微鏡的観察

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Although data obtained are yet incomplete, we have got some clinical evidences pointing to the positive association existing between administration of tetracycline analogs and pigmented deciduous teeth, the summary of which was given as follows. 1. Visual observation of the teeth could discriminate a variety of pigmentation due to administration of antibiotics ranging from yellow to brown, yellow-brown and darkish yellow-brown shades. So far as the present study is concerned, it is yet undecided whether this variation of shades is due to some kind of oxidative changes with progressive time or due to combined use of multiple antibiotic agents. 2. Observation on the progress of dental caries seemed to show that the progress was retarded by administration of antibiotics. 3. As far as the present cases are concerned, the presence of fluorescent streaks is localized in the dentine of the tooth, and all these streaks also ended within the dentine. 4. Time at which the antibiotics were given and dosis of administration would seem to have possible relation with the distances between each fluorescent streaks and their degree of brightness observed. 5. It would seem that the antibiotics as used in the present study had strong affinity to tissues in the course of calcification and to the dental hard tissues in formative stage. 6. It may be particularly notable that the cases presented in this study are consisted all of children by mature birth.
九州歯科学会の論文
1975-03-31

Tetracycline 系抗生物質が乳歯におよぼす影響 : とくに着色歯の螢光顕微鏡的観察

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