ポリフェノール配糖体のB16マウスメラノーマにおけるメラニン生合成阻害作用

概要

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Phenolic-α-glucosides were synthesized from polyphenols and starch using glucoside synthetase or cyclodextringlucanotransferase. The inhibition of melanogenesis in B16 mouse melanoma by fourteen polyphenol-α-glucosides was investigated, among which hydroquinone, and m- and p-coumaric acid derivatives inhibited melanogenesis (18% at 350 μM, 25% at 5000 μM, and 70% at 1000 μM, respectively) without inhibition of cell growth. Catechin-α-glucoside, which inhibits tyrosinase activity in mushroom, did not inhibit melanogenesis in mouse melanoma.
社団法人日本生物工学会の論文
1997-09-25