労働環境における気中有害金属物質の化学状態別分析法と粒径別リアルタイム分析法の開発

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The speciation and real-time analysis of airborne inorganic particulate matter were investigated as follows. A selective determination of the concentrations of vanadium(V) and vanadium(IV) in particulate matter was achieved by connecting HPLC to ICP-AES as a detector. The method was applied to confirm the purity used for the sample particle of an animal experiment to clarify acute toxicity in lung after exposure to V_2O_5. An analytical method of acetylacetonato-chromium by micellar electro kinetic chromatography (MEKC) was developed. Using the method, 160μg l^<-1> of chromium in aqueous solution was measurable. The speciation of particulate chromium was attempted using the method. Chromium(VI) oxide was detected selectively by adding acetylacetone to the sample without solvent and chromium in potassium dichromate particle was detected by using acetylacetone with 18-crown-8. The gas change function was added to a monodisperse aerosol generator (Differential Mobility Analyzer, DMA). Aerosol particles dispersed in the argon, "arogonsol", was made by the gas change DMA, and was directly introduced into ICP-MS without argon dilution to avoid plasma elimination. The performance of the device (DMA-ICP-MS) was evaluated by using various test particles from a pneumatic nebulizer. DMA-ICP-MS could analyze the airborne particula9te matter in the range of diameters of particles 20〜140 nm in real time.
2004-10-05