高性能配位子交換液体クロマトグラフィーによるRS-リンゴ酸の光学分離

概要

論文の詳細を見る
Direct chromatographic optical resolution of RS-malic acid without prederivatization was successfully achieved for the first time on a ligand exchange chiral column, MCI GEL CRS 10W. Addition of organic solvent, particularly acetonitrile, was effective for obtaining a small capacity factor as malic acid was found to be strongly adsorbed on the column. The degree of resolution (R_s) was raised by lowering the column temperature; however, resolution at room temperature was more suitable as column pressure simultaneously increased. Optical re-solutidn of malic acid in commercial apple juice and soft drinks was also effectively carried out, predicting a high possibility for quality control usage.
社団法人日本分析化学会の論文
1989-05-05