ビオチンと脂質代謝に関する研究

概要

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We examined histological changes, total lipid contents, phospholipid contents and cholesterol contents in several organs of control rats and of biotin deficient rats fed on a deficient diet for few weeks. Biotin contents in the urine and the liver of rats were also examined through which we could make it sure that they were biotin deficient. Through these examinations, we found that the increase of lipid in the blood caused by biotin deficiency indicates : (1) Imperfect utilization of adrenal and sexual hormones is caused by imperfect activation of lipid. (2) Disturbance of the protein-fat combiningrate in the blood is resulted from the decrease of liver phospholipid and cholesterolester, and the subsequent run-down of reabsorption to liver.