細菌のビタミンB_1合成および分解に関する研究 : (IV)アノイリナーゼIIによる2-METHYLTHIOTHIAMINEの分解とピリミジン部同族体の阻害作用

概要

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Evidence was presented to show that thiaminase of Bacillus aneurinolyticus actually hydrolyzes 2-methylthio analog of thiamine. The degradation products were identified by separating them by paper partition chromatography and measuring a ultraviolet absorption spectrum of the separated compounds. The hydrolysis of this compound was inhibited by thiamine pyrimidine more remarkably than thiamine was the case, and by thiamine thiazole which acted on thiamine only slightly. The hydrolysis of 2-methylthiothiamine was also inhibited by a high concentration of the pyrimidine moiety of this compound. 2-Methylthiothiamine was also decomposed by the staphylococcal extract. In this case, however, several pyrimidyl compounds revealed their inhibitory effects against the decomposition.
日本ビタミン学会の論文