肝カテーテル法によるビタミンA代謝の研究 : (V)健常犬における静脈内負荷カロチンに対する肝の態度に及ぼすトコフェロール同時投与の影響について

概要

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In order to study effect of α-tocopherol upon the conversion of β-carotene to vitamin A in the liver, the following experiments were made. Various amounts of aqueous emulsion of α-tocopherol, α-tocopheryl acetate and a definite amount of β-carotene were injected into the femoral vein of a healthy dog, and the determination of serum carotene, vitamin A alcohol and its ester contents of arterial and hepatic venous blood was made, before injection and 5,30,60 and 120 minutes after. A small dose of α-tocopherol stimulated β-carotene uptake in the liver and its conversion to vitamin A in the tissue. A large dose of α-tocopherol stimulated β-carotene uptake in the liver, while it had no effect upon the conversion to vitamin A. A large dose of α-tocopheryl acetate also stimulated β-carotene uptake in the liver, but inhibited the conversion to vitamin A.
日本ビタミン学会の論文