肝カテーテル法によるビタミンA代謝の研究 : (III)健常犬における静脉内負荷カロチンに対する肝の態度および肝機能障害児の血清カロチンおよびビタミンA値について

概要

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In order to study the function of the liver for β-carotene, administered, the following experiments were made. Various amounts of aqueous emulsion of β-carotene were injected into the femoral vein of a healthy dog, and the determination of serum carotene, vitamin A alcohol and its ester contents of arterial and hepatic venous blood was done before injection and 5,30,60 and 120 minutes after. A considerable amount of β-carotene administered intravenously was taken up in the liver. A part of β-carotene taken up in the liver was chiefly converted to vitamin A ester and a much smaller amount of vitamin A alcohol was also detected. The formed vitamin A ester was transferred into blood. Serum carotene and vitamin A contents of children with hepatic disorders were determined. The results showed that conversion of carotene to vitamin A was inhibited in some cases as a result of hepatic disorders.
日本ビタミン学会の論文