活性型ビタミンDによる細胞の分化と融合に関する研究

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概要

• 論文の詳細を見る

• Recently, much attention has been focused on the ubiquitous distribution of specific 1α,25-(OH)_2-D_3 receptors in normal and cancer cells. This suggests that the role of this vitamin in biology extends far beyond its classical role in mineral metabolism. Since 1981, we have been investigating the differentiating action of vitamin D compounds primarily in hematopoietic cells. 1α,25-(OH)_2-D_3 inhibits proliferation and induces differentiation of immature bone marrow cells and myeloid leukemia cells (M1, HL-60 and U937) preferentially into monocyte-macrophages. Furthermore, the vitamin promotes activation and fusion of mouse alveolar macrophages to form multinucleated giant cells. Of vitamin D_3 derivatives tested, 1α,25-(OH)_2-D_3 is the most potent in inhibiting cell growth and in promoting cell differentiation, activation and fusion. These results suggest the possibilities that 1α,25-(OH)_2-D_3 is involved in multinucleated osteoclast formation in bone and that the in vivo administration of vitamin D compounds to tumor-bearing animals decreases their tumorigenicity.

• 日本ビタミン学会の論文
• 1984-11-25

著者

• 阿部 悦子

  昭和大学歯学部

• 阿部 悦子

  昭和大 歯

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• 活性型ビタミンDによる細胞の分化と融合に関する研究
• ヒト血清中の25-Hydroxyvitamin D及び24R,25-DihydroxyvitaminDのCompetitive Protein Binding Assayについて
• 細胞の分化と融合に関する種々の因子
• Renal Activation of Vitamin D and Role of Sex Hormone on its Regulatory Systems
• 色素性乾皮症患者における紫外線防御と血中のビタミンDレベルの関係

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