ビタミンB_2欠乏症の電子顕微鏡的研究 : (III)ビタミンB_2欠乏シロネズミの副腎皮質の微細構造

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The ultrastructure of zona fasciculata of the adrenal cortex in rats fed with riboflavin-deficient diet was observed by electronmicroscopy. The degenerative and destructive changes were not observed in zona fasciculata of severely deficient rats. But in early stage of riboflavin-deficincy, the degeneration in the matrix and tubular cristae of the mitochondria were found. Those changes were associated with vacuolation and increased density of the matrix. The large bizarre mitochomdria infrequently appeared in the cells. Sometimes, a rod-form or queershaped inclusion was observed in the cytoplasm which has never described in the adrenal cortex and any other organ before. The presence of degenerated mitochondria and inclusion bodies were suggestive of morphological expression of the abnormal intermediate metabolic poducts that were produced by the interruption of ordinary metabolism along with riboflavin-deficiency. At 8th week of riboflavin-deficiency, the degeneration and destruction of the cells were not so severe as that was found in 6 weeks, and the lipid droplets were observed abundantly.
1968-04-25