ビタミンB_2欠乏症の電子顕微鏡的研究 : (II)ビタミンB_2欠乏シロネズミの腎の微細構造

概要

論文の詳細を見る
Several morphological changes in proximal convoluted epithelial cells, characterized by presence of swelling, vacuolation of the cells and bizarre mitochondria and enlarged or sometimes vacuolated mitochondria were observed in riboflavin-deficient rats. The cytoplasmic matrix decreased extremely in its electron density. Degenerated mitochondria and cytolysome were also frequently observed in these epithelial cells. Transport vesicules and tubules beneath the microvilli were prominently decreased in number and infolding of the basal plasmamembrane was diminished as well. The crystalline inclusion bodies in the matrix of the mitochondria were occasionally found. This finding was not reported previously. In spite of these obvious changes in proximal convaluted epithelial cells, the glomerular epithelium and capillary endothelium were almost similar in apperance to those found in control rats. Other cytoplasmic organelles such as endoplasmic reticulum and Golgi apparatus, were well preserved. It was suggested that these findings were characteristic in riboflavin-deficient state.
1968-04-25