ビタミンB_2欠乏症の電子顕微鏡的研究 : (I)ビタミンB_2欠乏シロネズミの肝実質細胞の微細構造

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In order to investigate the ultrastructural changes in the hepatic parenchymal cells in albino rats fed with riboflavin-deficient diet, the electronmicroscopical study was performed. The hepatic parenchymal cells were atrophied in general area, so the cytoplasm was apparently filled with the increased number of cytoplasmic organelles such as mitochondria and microbody. In severe riboflavin deficient rats the mitochondria increased in number with occasional large mitochondria and it's out membrane appered to have a saw-toothed margin, but the intramitochondrial cristae and granules showed no changes at all. The rough surfaced endoplasmic reticulum broke up into small vesicles or tubules and ribosome disappeared from the granular reticulum. The cytolysome was never found in any hepatic cells. In hepatic cells of rat fed with riboflavin-deficient diet for 8 weeks, the degenerative change became milder and smooth surfaced reticulum increased in number near the site of confluence with the rough surfaced reticulum. It was suggested that the hepatic cell changed created by 4 weeks riboflavin-deficiency were reversible even if were kept feeding on deficient diet up to 8 weeks.
1968-04-25