ビタミンB_1誘導体の抗炎症作用 : 3種の抗炎症効果検討法の相関を含めて
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概要
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Intraperitoneal1y administered TTFD (thiamine tetrahydrofurfuryldisulfide) and TPD (thiamine propyldisulfide) showed a strong inhibitory effect on carrageenin induced rat paw edema, while the strong anti-inflammatory effect was not observed by oral administration of TTFD and TPD. On the other hand, BTMP (S-benzoylthiamine monophosphate), DCET (O, S-dicarbethoxythiamine) and thiamine hydrochloride hardly inhibited carrageenin edema even with intraperitoneal route. None of TTFD, BTMP, DCET and thiamine hydrochloride showed a significant suppressive effect on ultraviolet erythema on guinea pigs and croton oil granuloma pouch in rats.
- 日本ビタミン学会の論文
- 1967-10-25
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