O-Butyrylthiamine Disulfideについての薬理学的研究

概要

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Pharmacological effects of O-butyrylthiamine disulfide (BuTDS) were studied in mice, rats, rabbits and dogs. BuTDS markedly prolonged the forced swimming time of mice. BuTDS reduced the development of the rat pad edema induced by serotonin, but exerted no significant effect on the formalin edema. BuTDS caused a blood pressure fall and a slight depression of the cardiac movement in large doses. These effects of BuTDS were less marked as compared to those of thiamine-HCl. BuTDS increased the tonus and movements of the rabbit intestine in situ, while it, on the contrary, reduced the motility of the isolated rabbit intestine. Contractions of the pyloric sphincter of the dog were increased in magnitude as well as in frequency, whereas the tone of the cardial region was slightly reduced by BuTDS.
日本ビタミン学会の論文
1966-06-25