ビタミンD大量負荷時のビタミンD代謝の研究

概要

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The distribution of vitamin D in the body of rachitic children or rats in case of massive dose of the vitamin administration, In peroral administration, a definite amount of vitamin D was appeared in serum of renal rachitic children only once at 6 hours after the administration of 12.5 and 15 mg of vitamin D. In rats, it was found in the serum at 6 and 12 hours after the admistration of 2.25 and 0.375 mg pro 100kg. In rat, the maximum vitamin D level was found at 12 hours after the administration. The vitamin D content at that time was highest in liver, followed by kidney and lung, while in spleen, bone and muscle were low. The faecal elimination of the vitamin on the first 2 days after the administration was found 7.2% in oily vitamin D solution and 3.4% in aqueous solution. In intramuscular injection of the vitamin, the utilization of the vitamin is supposed to be relatively low, because the vitamin was detected in the serum only in case of 4 times injection of 1.5 mg every other day and it was found only 1.7 μg/g of vitamin D in liver. The faecal elimination of the vitamin was a little more than by peroral administration. The vitamin D content of whole body of mouse after an injection of vitamin D was studied. The vitamin content of the whole body was about 65% of the injected dose after 48 hours, 55% after 96 hours and 32% after 144 hours.
日本ビタミン学会の論文
1962-10-25