Corynebacterium glutamicum変異株による安息香酸よりのカテコールの蓄積 : 細菌による安息香酸よりのカテコールの生産(第1報)

概要

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Mutant bM 9 which was induced from Corynebacterium glutamicum (AKU 509) by nitrosoguanidine mutagenesis accumulated catechol in a medium containng benzoic acid. Accumulation of catechol in the medium reached maximum 10-15 hr after inoculation and accumulated catechol was degraded rapidly on successive incubation. Maximal accumulation of catechol was achieved by the addition of 0.5% benzoic acid to the medium which was adjusted to pH 7.0 or 8.0. Yeast extract was a suitable nitrogen source for the catechol production and addition of glucose into the medium stimulated the production. Feeding of benzoic acid at 2.5 hr intervals in the course of the culture proved favorable for catechol production by bM 9.
社団法人日本生物工学会の論文
1976-11-25