プロテアーゼ, ペニシリン生産における初発通気攪拌条件の影響

概要

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The over-all volumetric oxygen transfer coefficient based on the gas phase, K_Ga and power requirement for agitation per unit volume of liquid in non- viable system, P_g were taken as typical values of the initial oxygen supply rate and agitation intensity. When these values were expressed as functions of operating variables, a relationship between fermentation product and agitation intensity could be derived using the oxygen transfer rate as a parameter. The present paper deals with the experimental method. In the case of thermostable protease production by Streptomyces rectus var. proteolyticus, the maximum protease activity in fermentation was expressed as a function of K_Ga, and was not affected by the power requirement for agitation (P_g) under conditions of constant K_Ga. These result can be ascrived to the fact that this microorganism grows from the early phase of protease production as a mycellial pellet, which is not affected by agitation intensity. The penicillin production by a mutant strain of Penicillium chrysogenum was greatly influenced by both K_Ga and P_g. The original data ware quoted from Bartholomew et al., and analyzed according to this method. As K_Ga value became smaller, a more profound effect of P_g was observed.
社団法人日本生物工学会の論文
1975-03-25