健康成人に Thiamin Tetrahydrofurfuryl Disulfide 含有製剤を単回および分割経口投与したときのビタミンB_1の体内動態 : 高齢者における総合ビタミン剤長期服用効果

概要

論文の詳細を見る
Bioavailability of preparations of thiamin tetrahydrofurfryl disulfide (TTFD) was examined in 6 healthy male adult volunteers. 1. No significant difference was observed in the AUC and urinary excretion of vitamin B_1 in the daily 100 mg TTFD administration between single and twice divided dose. 2. C_<max> AUC and urinary excretion of vitamin B_1 were two fold higher at orally once administration of 100mg of TTFD as compared with those at the 50 mg administration. Those were in dose-dependent manner and did not differ between difference of the tablets. 3. There were no differences in its pharmacokinetic parameters between postprandial administration of 100 mg TTFD and the administration at fasting, but variables in blood levels with respect to the absorption seemed to be smaller in postprandial administration than in fasting administration.
日本ビタミン学会の論文
1995-02-25