Saccharomyces carlsbergensis 4228におけるビタミンB_1とビタミンB_6との関連 : (IX) ビタミンB_1による増殖阻害と菌体内ビタミンB_6含量との関係

概要

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Relation between vitamin B_6 content of Sacch. carlsbergensis and its growth inhibition by thiamine on shaking culture was investigated. B_6 content of growing cells in the broth with thiamine was found to be always lower than that in the broth without thiamine. B_6 content of the inoculum and its increase rate according to the growth were important to regulate growth of the yeast in the broth with thiamine. Growth inhibition by thiamine was observed only when inoculum (low B_6 content) from the apparent stationary phase was used. Increase of B_6 content was started just before the beginning of growth and B_6 content in cells was the highest in exponential growth phase and the addition of thiamine reduced the increase of B_6 content. Similar decrease of B_6 content by thiamine was observed in thiamine-adapted Sacch. carlsbergensis and two strains of Sacch. cerevisiae of which the growth was not inhibited by thiamine. However, B_6 contents of inoculum and growing cells were the lowest in Sacch. carlsbergensis. Growth retardation of Sacch. carlsbergensis by thiamine is reasonably explained by the disturbance of biosynthesis of vitamin B_6 in the cells.
日本ビタミン学会の論文
1969-11-25