呼吸器感染モデルにおける気道上皮細胞の免疫学的役割 : 気道上皮細胞由来のケモカインの解析(びまん性肺疾患に対する分子生物学的アプローチ : 間質性肺炎から肺気腫まで)(第24回日本気管支学会総会)

概要

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Chemokines have been defined by their capacity to regulate traffic of immune cells. Here, we demonstrate that expression of β-chemokine RANTES in host cells (especially airway epithelial cells) infected with a respiratory virus enables immune cells to more efficiently migrate across the epithelial barrier. On this study, the patterns for specific apical sorting of RANTES may serve to mediate the level and directionality of immune cell traffic through epithelium (distinct from endothelium). This chemoattractant activities may efficiently regulate traffic of mucosal immune cell during normal host defense and abnormal inflammatory disease in the airway. Especially, RANTES has the pattern of preferential apical secretion provides for a soluble chemical gradient for immune cells movement from the subepithelium to the mucosal surface and maintenance there. In addition, we investigated RANTES deficiencies affect the delay on infiltrating cells movement on immunity response, and then the reduction of chemotactic activities (particular activated macrophages trafficking) were observed in airway epithelium level with viral infected RANTES deficient mice. The results therefore establish a distinct action of chemokines in regulating immune cell migration and the primary importance of this component of innate immunity for host defense.
日本呼吸器内視鏡学会の論文
2001-12-25