自律神經機能調節機構心臓機能(心搏)調節機構(第2報)

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In the previous paper, some facts concerning heart-rate regulation were studied using drug induced bradycardia and tachycardia in the following : 1) Ablation experiments, in other words, vagus and anastomosis from Ggl. stellatum to vagus (Rami anastomosa) were cut at each point as follows : (Ggl. stellatum-rami anastomosa of vagus-N. aorticus-N. vagus-Ggl. nodosum) or extirpation of Ggl. tellatum.2) Blocking experiments by the use of some blockades such as procaine HCl, procaine amide, C_6,TEA, atropine, atropine-N-methyl, chlorpromazine, dibenamine, DHK, Hydergine and etc.From the results above, it was resumed that : 1) In the vagus of rabbit, there were centripetal and fugal paths which concerned veratrine (Ver) bradycardia, and this bradycardia occurred through this Vago-vagal reflex. On the other hand, the path in vagus concerning adrenaline (Adr) or digitalis (Dig), histamine (Hist) or BaCl_2,was not centripetal but solely fugal, and these bradycardia occurred through Sympathico-vagal reflex (Tokita).2) The balance between sympathicus and parasympathicus was maintained not only at periphery, but regulated at centre by reflexes through centripetal path (anastomosis and vagus).In this paper, above facts were further investigated to ascertain, anesthetizing both vagi with various concentrations of procaine HCl, instead of cutting nervi.Ver was injected intravenously after both vagi were infiltrated by 0.1% Procaine HCl, then heart-rate diminished to 80-90% of before injection (14 cases), but in contrast to this fact, Ver bradycardia was 20-50% in the rabbits without procaine anesthesia.This fact can be remarked that Ver bradycardia almostly disappeared with 0.1% of procaine anesthesia.In this condition, Adr bradycardia (15γ/kg, i. v.) appeared in all of 13 cases (Heart-rate were 40-50% of average). Equal to Adr, drug induced bradycardia occurred as follows : Hist (0.1 mg/kg, i. v.), 6 cases in 11. Heart-rate were 70% of before the injection. (Without procaine anesthesia, Hist induced bradycardia were in 10 cases of 16) : BaCl_2,5 cases in 7 (Control, 13 in 16) : Ext of Dig leaf (20 mg/kg), i. v., every 5 min, 5-10 times), 5 cases in 6 (Control 9 in 12 cases).From the facts above, it can be resumed that, after 0.1% of procaine anesthesia, Adr, Hist, Dig or BaCl_2 bradycardia still remained, though Ver bradycardia disappeared. In other words, the centripetal path was more sensitive to procaine HCl (0.1%) than the fugal, and even when the centripetal was anesthetized, the fugal was intact. This fact was proved by electrical stimulation.When both vagi were infiltrated with 0.02% of procaine HCl, occurred the bradycardia by Ver (0.1 mg/kg, i. v., 10 cases in 11), Adr (4 cases in 4), Hist (6 cases in 11), BaCl_2 (4 cases in 7), Dig (4 cases in 4). These facts showed, that both centripetal and fugal paths were intact, when anesthetized with 0.02% of procaine HCl.Furthermore, when both vagi were infiltrated by 0.5% of procaine HCl, occurred Ver bradycardia, and also Adr (15γ/kg, 2 cases in 8), Dig (0 cases in 2), BaCl_2 (10 mg/kg, 0 cases in 6), Hist (0.1 mg/kg, 0 cases in 7). By these facts it can be resumed that centripetal paths in vagus were completely blocked with 0.5% of procaine HCl.SUMMARY While both vagi were anesthetized with 0.1% (not 0.02% or 0.5%) of procaine HCl, bradycardia by Adr, Dig, Hist or BaCl_2 existed, even if Ver bradycardia disappeared. And from this fact, the results reported in the previous paper were further ascertained by the experiments with the concentration of 0.1% of procaine HCl.
社団法人日本循環器学会の論文
1958-05-20

自律神經機能調節機構心臓機能(心搏)調節機構(第2報)

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