ペフラゾエートの抗菌特性および作用機作

概要

論文の詳細を見る
Pefurazoate, pent-4-enyl N-furfuryl-N-imidazol-1-ylcarbonyl-DL-homoalaninate, was highly toxic to wide range of phytopathogenic fungi including Ascomycetes, Basidiomycetes and Deuteromycetes, but less toxic to Phycomycetes. Although the compound hardly inhibited spore germination of Fusarium monilforme, Cochliobolus miyabeanus and Pyricularia oryzae at 100 μg/ml, germ tubes of treated spores were swollen, abnormally branched and shorten at 0.1-1.0 μg/ml. Gas chromatographic analysis indicated that ergosterol biosynthesis of F moniliforme was strongly suppressed and the concomitant accumulation of 24-methylene-dihydro-lanosterol, obtusifoliol and other unknown substances were observed. This result suggested that pefurazoate particularly inhibited the demethylation at C-14 position of 24-methylenedihydrolanosterol in sterol biosynthetic pathway. Pefurazoate also affected the production of gibberellin-like substances in culture liquid of F. monilforme at a low concentration which hardly affected the inhibition of mycelial growth.
日本植物病理学会の論文
1991-04-25