Akt Induces Endothelial Cell Senescence via a p53/p21-Dependent Pathway
スポンサーリンク
概要
- 論文の詳細を見る
- 社団法人日本循環器学会の論文
- 2003-03-01
著者
-
Komuro Issei
Department of Cardiovascular Science and Medicine, Chiba University graduate School of Medicine
-
Miyauchi Hideyuki
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
-
Minamino Tohru
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
-
Tateno Kaoru
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
-
Tateno Kaoru
Kimitsu Chuo Hospital
-
Miyauchi Hideyuki
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
-
Minamino Tooru
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
-
Yoshida Toshihiko
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
-
Minamino Tooru
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
-
Komuro Issei
Department Of Cardiovascular Medicine Chiba University School Of Medicine
-
Taneno Kaoru
Dept. Of Cardiovascular Medicine Chiba Graduate School Of Medicine
-
Minamino Tooru
Department Of Cardiovascular Science
-
Yoshida Toshihiko
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
-
Yoshida Toshihiko
Department Of Applied Physics Faculty Of Engineering Osaka University
-
Minamino Toru
Department Of Cardiovascular Science And Medicine
-
Komuro Issei
Department Of Cardiovascular Medicine
関連論文
- DPE-008 Bone Marrow Derived Mononuclear Cells Improve the Cardiac Function of Dilated Cardiomyopathy Models via Gr-1 Positive Cells-secreted Factors(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The
- PE-424 Bone Marrow Derived Monomuclear Cells Transiently Improve the Cardiac Function of Dilated Cardiomyophthy Models via Gr-1 Positive cells-secreted Factors(Heart failure, basic(04)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the J
- PE-364 Preliminary Report of a Multicenter Cohort Study of Myocardial Viability Assessment by Gated^Tc-Sestamibi SPECT at Rest(Nuclear cardiology-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 4 p53 as a New Therapeutic Target for Heart Failure(Novel Therapeutic Strategies against Heart Failure,KSC-JCS Joint Symposium (KSC-JCS Joint Symposium) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Multivalent ligand-receptor interactions elicit inverse agonist activity of AT_1 receptor blockers against stretch-induced AT_1 receptor activation
- OE-164 Atg7 is Essential for Starvation-induced And Constitutive Autophagy in the Hearts(Molecular biology, myocardium (M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-020 Molecular and Structural Basis for Mechanical Stress-induced Activation of AT Receptor(Cardiovascular pharmacology, basic/clinical(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-009 Crucial roles of PDK1 in the regulation of β-adrenergic response and cell survival in the hearts(Novel Pathophysiological Mechanisms of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
- Angiotensin II Type 1a Receptor Signals are Involved in the Progression of Heart Failure in MLP-Deficient Mice
- OJ-256 Erythropoietin Prevents Apoptotic Cell Death Through Erythropoietin Receptor-mediated Cytoprotective Signaling Pathways(Growth factor/Cytokine-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-056 Erythropoietin Prevents LV Remodeling after Myocardial Infarction through Erythropoietin Receptor-Induced Signaling Pathways in the Heart(Acute myocardial infarction, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 1 p53-induced Inhibition of Angiogenesls Causes Cardiac Dysfunction during Pressure Overload(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-242 Erythropoietin Has an Ischemic Postconditioning-like Effect on Myocardium through a Direct Action on Cardiomyocytes(Myocardial ischemia-reperfusion, basic/clinical-2 (M) OJ41,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeti
- 1 Actions on Angiotensin II Receptor by Angiotensin II, Mechanical Stress, And Inverse Agonists(Molecular Mechanism of Hypertensive Heart Failure,Symposium 5 (SY5) (H),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Cardioprotective Effects of Granulocyte Colony-stimulating Factor in Chronic Hibernating Swine Myocardium(Old Myocardial Infarction/Remodeling 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Beneficial Effects of G-CSF on Coronary Atherosclerotic Lesion in Watanabe Heritable Hyperlipidemic Rabbits(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Direct Effects of G-CSF on Cardioprotection against Ischemia/Reperfusion Injury(Myocardial Ischemia-reperfusion, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PPARgamma Ligand Inhibits the Progression of Inflammation in Myosin-induced Autoimmune Myocarditis in Rats (Myocarditis, Basic/Clinical 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- G-CSF Prevents Cardiac Remodeling after Myocardial Infarction by Activating Jak/STAT in Cardiomyocytes(Vascular Regeneration (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-482 G-CSF Prevents Cardiac Remodeling after Acute Myocardial Infarction in Swine(Old Myocardial Infarction/Remodeling 1 (IHD) : OJ59)(Oral Presentation (Japanese))
- Amelioration of Hypertensive Heart Failure by Amlodipine May Occur via Antioxidative Effects
- PE-065 Prevalence of Adult Patients with Congenital Heart Disease in Japan(PE011,Congenital Heart Disease (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-620 Consistency of Detection of Abnormal Late-Enhancement in Left-Ventricular-Myocardium by Multislice-CT in Myocardial Disease in Comparison with Cardiac-Magnetic-Resonance Using Segment-versus-Segment Analysis(PJ104,CT/MRI (Myocardium) 3 (I),Poster S
- PJ-617 Origin of Ventricular-Arrhythmias by 12-Lead Ambulatory-ECG and Relationships with Late-Enhancement-Cite in Left-Ventricle by MRI and Multislice-CT in Hypertrophic-Cardiomyopathy and Myocardial-Infarction(PJ104,CT/MRI (Myocardium) 3 (I),Poster Sess
- PJ-612 Clinical Significance of Fat Replacement in the Moderator Band of the Right-Ventricle in Multislice-CT in Comparison with Abnormal Conduction Systems(PJ103,CT/MRI (Myocardium) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of Th
- PJ-611 Multi-Slice Computed Tomography Reveals the Non-uniform Wall Thickness of the Left Atrial Antrum in patients with Atrial Fibrillation(PJ103,CT/MRI (Myocardium) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circu
- PJ-620 Consistency of Detection of Abnormal Late-Enhancement in Left-Ventricular-Myocardium by Multislice-CT in Myocardial Disease in Comparison with Cardiac-Magnetic-Resonance Using Segment-versus-Segment Analysis(PJ104,CT/MRI (Myocardium) 3 (I),Poster S
- PJ-617 Origin of Ventricular-Arrhythmias by 12-Lead Ambulatory-ECG and Relationships with Late-Enhancement-Cite in Left-Ventricle by MRI and Multislice-CT in Hypertrophic-Cardiomyopathy and Myocardial-Infarction(PJ104,CT/MRI (Myocardium) 3 (I),Poster Sess
- PJ-612 Clinical Significance of Fat Replacement in the Moderator Band of the Right-Ventricle in Multislice-CT in Comparison with Abnormal Conduction Systems(PJ103,CT/MRI (Myocardium) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of Th
- PJ-611 Multi-Slice Computed Tomography Reveals the Non-uniform Wall Thickness of the Left Atrial Antrum in patients with Atrial Fibrillation(PJ103,CT/MRI (Myocardium) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circu
- FRS-009 Crucial roles of PDK1 in the regulation of β-adrenergic response and cell survival in the hearts(Novel Pathophysiological Mechanisms of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
- OJ-242 Erythropoietin Has an Ischemic Postconditioning-like Effect on Myocardium through a Direct Action on Cardiomyocytes(Myocardial ischemia-reperfusion, basic/clinical-2 (M) OJ41,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeti
- PJ-611 Multi-Slice Computed Tomography Reveals the Non-uniform Wall Thickness of the Left Atrial Antrum in patients with Atrial Fibrillation(PJ103,CT/MRI (Myocardium) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circu
- PE-485 New Strategies of Anticoagulation Management in the Periprocedual Period for Atrial Fibrillation Ablation(PE081,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 4 (A),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circ
- PE-072 What Kind of Patients is Susceptible to the Detrimental Effects of Chronic Pacing from the Right Ventricular Apex?(PE012,Heart Failure (Treatment) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- OE-238 Adult Murine Heart Derived Clonal Expanded Sca-1 Positive Cell Sheet Ameliorates Cardiac Dysfunction after Myocardial Infarction(Regeneration(angiogenesis/myocardial regeneration)(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting
- OJ-248 A Pathological Role of Semaphorin3E/PlexinD1 in Impaired Angiogenesis of Diabetes(OJ42,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation
- OE-093 Critical Role of Adipose-p53 in Type 2 Diabetes(OE16,Diabetes (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-073 Cardiac 12-lipoxygenase-induced Inflammation is Involved in Heart Failure(FRS15,Novel Molecular Mechanisms of Heart Failure 1 (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 6 ER Stress-response Transcription Factor ATF6 Plays a Critical Role in Maintaining Cardiac Function under Physiological and Pathological Conditions(Subcellular Remodeling in the Failing Heart,Symposium 10 (SY-10) (A),The 73rd Annual Scientific Meeting of
- PJ-174 Semaphorin 3E/Plexin D1 as a Novel Target for Therapeutic Angiogenesis(Regeneration(angiogenesis/myocardial regeneration)(04)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-039 CaMKIIδ Plays a Critical Role in Systolic Dysfunction of Dilated Cardiomyopathy(Cardiomyopathy, basic/clinical(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-268 A protective role of brain-derived neurotrophic factor in cardiac remodeling after myocardial infarction(Acute myocardial infarction, basic(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-088 Critical Role of Adipose Senescence in Insulin Resistance and Vascular Dysfunction(New Insights into Metabolic Syndrome(01)(H),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-008 Cardiac 12-lipoxygenase is critically involved in heart failure(Novel Pathophysiological Mechanisms of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-006 Targeting p53 for therapy against myocardial infarction(Novel Pathophysiological Mechanisms of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 4 In-vivo Monitoring of Manganese-labeled White Blood Cells for Regenerative Therapy in the Ischemic Rat(Role of Molecular Imaging for Cardiovascular Regeneration Treatments,Topic 2 (TP-2) (I),Special Program,The 72nd Annual Scientific Meeting of the Japa
- PJ-259 Activation of the ER Stress-Related Transcription Factor ATF6 is Important for Cardiac Remodeling after Myocardial Infarction(Myocardial ischemia/reperfusion, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-545 Atologous Transplantation of Peripheral Blood Mononuclear Cells for Patients with Critical Limb Ischemia : Long Term Outcomes(Peripheral circulation/Vascular disease-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-538 Amlodipine Inhibits Vascular Cell Senescence and Protects against Atherogenesis through the Mechanism Independent of Calcium Channel Blockade(Molecular biology, vascular-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-412 Activation of SIRT1, a Longevity Gene, Prevents the Development of Diabetic Vasculopathy by Inhibiting Endothelial Senescence(Diabetes/Obesity/Metabolic syndrome-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-264 Pathological Role of Nitric Oxide in Impaired Circadian Clock Associated with Aging(Neurohumoral factors-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-204 A Protective Role of Brain-Derived Neurotrophic Factor in Cardiac Remodeling after Myocardial Infarction(Cardiac function, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-149 Hyperglycemia-induced Senescence of Endothelial Cells through the p53 Deacetylase SIRT1(Diabetes/Obesity/Metabolic syndrome-10 (H) PJ25,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-673 Increased Subcutaneous Fat Accumulation Have a Protective Role Against Subclinical Atherosclerosis in Asymptomatic Subjects Who Underwent General Health Screening(Diabetes / Obesity / Metabolic syndrome(13)(H),Poster Session(Japanese),The 72nd Annu
- FRS-054 Semi-Quantitative Relationship of Serum Ferritin Concentration with Aortic Calcification in Healthy Subjects(Emerging Technologies in MDCT(I),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Noninvasive Detection of Cardiac Repair After Acute Myocardial Infarction in Rats by 111In Fab Fragment of Monoclonal Antibody Specific for Tenascin-C
- Exercise echocardiography in the evaluation of severity of functional mitral regurgitation in patients with heart failure
- Noninvasive Detection of Experimental Autoimmune Myocarditis in Rats by [In-111]-Anti-Tenascin-C Antibody and SPECT
- OE-006 Impact of Pioglitazone on Serum Lipid-profile and Coronary Plaque Volume in Patients with Non- and Early-diabetes : A Prospective Randomized IVUS Study(OE01,Cardiovascular Pharmacology (Clinical) (H),Oral Presentation (English),The 73rd Annual Scie
- Cardiomyocytes Fuse with Surrounding Non-Cardiomyocytes and Re-enter the Cell Cycle(The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-359 Cytokine Therapy Prevents Left Ventricular Remodeling And Dysfunction after Myocardial Infarction Through Neovascularization.(Cardiovascular Pharmacology, Basic/Clinical 4 (H) : PE61)(Poster Session (English))
- PE-197 Adult Cardiac Sca-1 Positive Cells Differentiate into Beating Cardiomyocytes(Development and Differentiation 1 (M) : PE34)(Poster Session (English))
- OJ-446 Cerivastatin inhibits the development of heart failure by reducing cardiac apoptosis and cytokine expression in Dahl rat heart failure model(Heart Failure, Basic 3 (M) : OJ54)(Oral Presentation (Japanese))
- OE-368 Ligand-independent activation of angiotensin II type 1 receptor by mechanical stretch(Cardiac Hypertrophy, Basic and Clinical 1 (M) : OE46)(Oral Presentation (English))
- OE-364 Exercise-induced upregulation of _1-adrenergic receptor is involved in the upregulation of Hsp70 through enhanced activity of ERKs(Cardiac Hypertrophy, Basic and Clinical 1 (M) : OE46)(Oral Presentation (English))
- OE-359 Calcium/Calmodulin and Calcineurin Signaling is Involved in Cell Fusion between Adult Stem Cells and Cardiomyocytes(Development and Differentiation 2 (H) : OE45)(Oral Presentation (English))
- OE-105 Granulocyte-colony stimulating factor prevents transition from left ventricular hypertrophy to diastolic heart failure in hypertensive rats(Heart Failure, Basic 1 (M) : OE13)(Oral Presentation (English))
- OE-004 Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction(Acute Myocardial Infarction, Basic 1 (IHD) : OE1)(Oral Presentation (English))
- 2 Diphtheria toxin-induced autophagic death of cardiomyocytes plays a pathogenic role in mouse model of heart failure(Young Investigator's Award Finalists Lectures (YIA))(Special Program)
- Effects of Torasemide on Heart Failure
- Rat Neonatal Cardiomyocytes Fuse with Mammalian Somatic Cellsand Reenter Cell Cycle
- Mechanical Stress and Calcium Signaling Involve Trans-Differentiation of Skeletal Muscle Derived Cells
- Angiotensin II Type 1 Receptor May Act as a Mechanoceptor in Stretch-Induced Cardiomyocyte Hypertrophy
- Heat Shock Proteins Are Upregulated in Exercised-lnduced Cardiac Hypertrophy But Not in Pressure Overload-Induced Cardiac Hypertrophy
- The feasibility of transdifterentiation of skeletal myoblasts or skeletal muscle derived stem cells into cardiomyocytes
- The feasibility of induction of cardiomyocyte-like cells after myoblast transplantation
- PE-602 Homing and Differentiation of Intravenously Transplanted Cardiac Side Population Cells in Injured Myocardium(Molecular biology, myocardium-2 (M) PE106,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulati
- PE-564 Trichostatin A Induces Differentiation of Cardiac Side Population Cells into Beating Cardiomyocytes(Development and differentiation-3 (M) PE97,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Socie
- PJ-441 Clinical Relevance of Fat-Replacement of the Right-Ventricular-Myocardium Determined by Multislice-CT : Relationship with Aging, Obesity, and the Occurrence of Ventricular Arrhythmia(Cardiomyopathy, basic/clinical-6, The 71st Annual Scientific Meet
- PE-317 Utility of 64-Multislice Computed Tomography Compared with Invasive Left Ventriculogram for Quantitative 4-Dimensional Volumetric Analysis of Left Ventricle(CT/DSA-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-227 Can Pulsed Tissue Doppler Imaging Provide Prognostic Information in Patients with Chronic Pulmonary Thromboembolism?(Echo/Doppler-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-199 Significance of Calcified and Non Calcified Plaques of Coronary Arteries for Presence of Myocardial Infarction Evaluated by Multislice Computed Tomography(Atherosclerosis, clinical-04, The 71st Annual Scientific Meeting of the Japanese Circulation
- I-123 BMIPP/TI-201 dual isotope myocardial imaging is useful for screening the patient with atypical and resting chest pain
- Reversible defect of dipyridamole stress sestamibi imaging within 4 days after AMI who underwent revascularization is predictable of ischemic event
- Molecular Mechanism of Mechanical Stress-induced Cardiac Hypertrophy
- Bare Metal Stent Restenosis Is Benign Clinical Entity in Japanese Patients
- Long-term Clinical Outcomes After Sirolimus-Eluting Stent Implantation in Dialysis Patients
- Silent Very Late Thrombotic Occlusion of Sirolimus-Eluting Stent Confirmed by Directional Coronary Atherectomy
- Early Stent Thrombosis Because of Stent Dislodgement in a Coronary Artery Aneurysm
- Prognostic Significance of Cystatin C in Patients With ST-Elevation Myocardial Infarction
- Effects of Antiarrhythmic Drugs on the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Current
- PJ-785 The Extracellular Matrix Protein Periostin in the Heart Plays a Critical Role in Cardiac Hypertrophy and Ventricular Remodeling(PJ132,Heart Failure, Basic (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation
- PJ-377 64-slice CT Measurements of Soft and Fibrotic Plaques and Thrombi Confirmed by Intravascular Ultrasound in Culprit Coronary Arteries in Acute-Coronary-Syndromes(PJ064,ACS/AMI (Clinical/Diagnosis) 2 (IHD),Poster Session (Japanese),The 73rd Annual Sc
- PJ-329 Effects of Statin Therapy on Patient with Paroxysmal Atrial Fibrillation(PJ056,Preventive Medicine/Epidemiology/Education 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-053 Utility of Emergency 64-Slice CT Acquisition in Anginal Chest Pain and Suspected Acute Coronary Syndromes Just before Invasive Coronary Angiogram(PJ009,CT/MRI (Coronary/Vascular) 4 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of
- PE-431 Long-term Clinical Outcome after Sirolimus-eluting Stent Implantation in Dialysis Patients(PE072,Coronary Revascularization, PCI (DES) 7 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- Anti-Aging Medicine in Cardiovascular Disease
- Costarring Statins With ARBs : – Going to Be a Smash Hit? –
- Transition From Asymptomatic Diastolic Dysfunction to Heart Failure With Preserved Ejection Fraction : – Roles of Systolic Function and Ventricular Distensibility –