Effect of Smoking on Endothelial Function and Wall Thickness of Brachial Artery
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概要
- 論文の詳細を見る
Background Impaired flow mediated dilatation (FMD) and increased wall thickness (WT) of the brachial artery have been associated with atherosclerosis and its risk factors. In this study we sought to determine brachial artery wall thickness in chronic smokers and the instantaneous effect of smoking on brachial artery endothelium dependent vasodilator function in smokers and non-smokers. Method and Results Using a high-resolution ultrasound, WT of posterior brachial artery wall, the diameter of brachial artery at rest and during reactive hyperemia (FMD %), as well as after sublingual administration of nitroglycerine (nitroglycerine mediated dilatation (NMD) %) was measured in 20 smokers and 20 non-smokers. Wall thickness (WT) of the posterior brachial artery wall and the wall index (WI) were greater in smokers than non-smokers. The baseline brachial artery diameter was comparable in smokers and non-smokers. Flow mediated dilation (FMD) was found to be less in smokers than non-smokers. The NMD in smokers also did not differ significantly from that in non-smokers. Flow mediated dilation significantly reduced after smoking compared to baseline in both groups. However, NMD remained unchanged after smoking in both groups. Conclusions Increased WT and impaired endothelium-dependent dilatation of brachial artery suggests that cigarette smoking disrupts vessel wall morphology long before atherosclerosis is manifest.
- 社団法人日本循環器学会の論文
- 2004-11-20
著者
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Barutcu Irfan
Department Of Cardiology Kartal Kosuyolu Yuksek Ihtisas Education And Research Hospital
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Esen Ali
Department Of Cardiology Kartal Kosuyolu Yuksek Ihtisas Education And Research Hospital
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Barutcu Irfan
Kosuyolu Heart Education And Research Hospital Department Of Cardiology
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Turkmen Muhsin
Department of Cardiology, Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
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ESEN ALI
Kosuyolu Heart Education and Research Hospital Department of Cardiology
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KAYA DAYIMI
Kosuyolu Heart Education and Research Hospital Department of Cardiology
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ESEN OZLEM
Istanbul Memorial Hospital Department of Cardiology
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ONRAT ERSEL
Kosuyolu Heart Education and Research Hospital Department of Cardiology
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Esen All
Department Of Cardiology Kartal Kosuyolu Yuksek Ihtisas Education And Research Hospital
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Kirma Cevat
Department Of Cardiology Kartal Kosuyolu Yuksek Ihtisas Education And Research Hospital
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Kirma Cevat
Cardiology Kartal Kosuyolu Yuksek Ihtisas Education And Research Hospital
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Acar Murat
Kocatepe University Faculty Of Medicine Department Of Radiodiagnostic
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Melek Mehmet
Department Of Cardiology Faculty Of Medicine Afyon Kocatepe University
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Kaya Dayimi
Kocatepe University Faculty of Medicine, Department of Cardiology
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Melek Mehmet
Kocatepe University Faculty of Medicine, Department of Cardiology
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Onrat Ersel
Kocatepe University Faculty of Medicine, Department of Cardiology
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Degirmenci Bumin
Kocatepe University Faculty of Medicine, Department of Radiodiagnostic
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Turkmen Muhsin
Kosuyolu Heart Education and Research Hospital, Department of Cardiology
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Kirma Cevat
Kosuyolu Heart Education and Research Hospital, Department of Cardiology
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Degirmenci Bumin
Kocatepe University Faculty Of Medicine Department Of Radiodiagnostic
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TURKMEN Muhsin
Kosuyolu Health & Research Hospital, Istanbul, Turkey.
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