Plasma Nitric Oxide Level and Its Role in Slow Coronary Flow Phenomenon
スポンサーリンク
概要
- 論文の詳細を見る
Previous studies have suggested that microvascular abnormalities and endothelial dysfunction cause slow coronary flow (SCF). The objective of this study was to assess the plasma nitric oxide (NO) level and determine its role in the pathogenesis of SCF phenomenon. Thirty-six patients with SCF (group 1) and otherwise patent coronary arteries and 34 subjects with normal coronary flow (group 2) were included in the study. Coronary flow was quantified according to the TIMI Frame Count (TFC) method. Brachial artery endothelium-dependent flow-mediated dilatation (FMD) and nitroglycerin (NTG)-induced endothelium-independent dilatation were studied in both groups. In addition, plasma NO levels were measured and their contribution to FMD was determined. The sex, age, body mass index, arterial blood pressure, and heart rate distributions were similar in both groups. TFC was significantly higher in group 1 compared to group 2 for each artery. The plasma NO level was lower in patients with SCF than in control subjects (18.4 ± 4.4 versus 25.2 ± 6.3 μmol/L P = 0.001). FMD was significantly smaller in group 1 than in group 2 (4.0 ± 3.2% versus 10.6 ± 5.8%, P = 0.0001). The percent NTG-induced dilatation was similar in the two groups (16.8 ± 1.1% versus 17.1 ± 1.1%, P = 0.42). In group 1, the plasma NO level was correlated with percent of FMD. Also, the plasma NO level was inversely correlated with TFC for each artery. Reduced NO bioactivity as well as impaired FMD support the presence of endothelial damage in the pathogenesis of SCF phenomenon.
著者
-
Barutcu Irfan
Department Of Cardiology Kartal Kosuyolu Yuksek Ihtisas Education And Research Hospital
-
Esen Ali
Department Of Cardiology Kartal Kosuyolu Yuksek Ihtisas Education And Research Hospital
-
Karakaya Osman
Department Of Cardiology Kartal Kosuyolu Yuksek Ihtisas Education And Research Hospital
-
Turkmen Muhsin
Department Of Cardiology Kartal Kosuyolu Yuksek Ihtisas Education And Research Hospital
-
Gullu Hakan
Department Of Cardiology Inonu University Medical Faculty
-
Sezgin Alpay
Department Of Cardiology Inonu University Medical Faculty
-
Gullu Hakan
Department of Cardiology, Baskent University Practice and Research Hospital
-
Sezgin Nurzen
Biochemical Department, Baskent University Practice and Research Hospital
関連論文
- Relationship Between Endothelial Function and Coronary Risk Factors in Patients With Stable Coronary Artery Disease
- Early Effects of Percutaneous Mitral Valvuloplasty on Left Atrial Mechanical Functions
- Decreased Serum Lipoprotein Levels as a Guide for Clinical Severity in Patients with Idiopathic Dilated Cardiomyopathy
- Impaired Left Ventricular Filling in Patients with Essential Hyperhidrosis : An Echo-Doppler Study
- Contribution of Plasma Matrix Metalloproteinases to Development of Left Ventricular Hypertrophy and Diastolic Dysfunction in Hypertensive Subjects
- Peripheral Vascular Endothelial Function in Essential Hyperhidrosis
- Acute Cigarette Smoking-Induced Hemodynamic Alterations in the Common Carotid Artery : A Transcranial Doppler Study
- Effect of Smoking on Endothelial Function and Wall Thickness of Brachial Artery
- Plasma Nitric Oxide Level and Its Role in Slow Coronary Flow Phenomenon
- Dilatation of the Ascending Aorta Is Associated with Low Serum Prolidase Activity
- Impaired Cerebral Circulation in Patients with Slow Coronary Flow
- Coronary and Systemic Stent Embolization During Percutaneous Coronary Interventions A Single Center Experience:A Single Center Experience
- Decreased Heart Rate Recovery in Patients With Heart Failure Effect of Fluvastatin Therapy:Effect of Fluvastatin Therapy
- A Case of Vasospastic Angina Resulting From Coronary Emboli in a Patient With Prosthetic Valves
- Comparison of Exercise QRS Amplitude Changes in Patients with Slow Coronary Flow Versus Significant Coronary Stenosis
- Prognostic Importance of Predischarged Troponin T Levels in Acute Anterior Myocardial Infarction