Designing Scaffolds of Peptides for Phage Display Libraries
スポンサーリンク
概要
- 論文の詳細を見る
Phage display is a powerful method for the discovery of peptide ligands that are used for analytical tools, drug discovery, and target validations. Phage display technology can produce a huge number of peptides and generate novel peptide ligands. Recently, phage display technology has successfully managed to create peptide ligands that bind to pharmaceutically difficult targets such as the erythropoietin receptor. As a result of the structural analysis of their ligands, we found that the conformational design of peptides in library is important for selecting high-affinity ligands that bind to every target from a phage peptide library. Key issues concern constraints on the conformation of peptides on the phage and the development of chemically synthesized peptides derived from peptides on phage. This review discusses studies related to the conformation of peptides selected from phage display peptide libraries in addition to the conversion from peptides to non-peptides.
- 社団法人日本生物工学会の論文
- 2005-05-25
著者
-
Tokui Noritaka
Department Of Clinical Epidemiology Institute Of Industrial Ecological Sciences University Of Occupa
-
Tokui Noritaka
Department Of Clinical Epidemiology Institute Of Industrial Ecology Science University Of Occupation
-
UCHIYAMA FUMIAKI
Department of Nutritional Sciences, Graduate School of Nutritional Sciences, Nakamura Gakuen Univers
-
TANAKA YUKO
Central Pharmaceutical Research Institute, Japan Tobacco Inc.
-
MINARI YOSHIMI
Faculty of Nutritional Sciences, Nakamura Gakuen University
-
Minari Yoshimi
Faculty Of Nutritional Sciences Nakamura Gakuen University
-
Uchiyama Fumiaki
Department Of Nutritional Sciences Graduate School Of Nutritional Sciences Nakamura Gakuen Universit
-
Tanaka Yuko
Central Pharmaceutical Research Institute Japan Tobacco Inc.
関連論文
- Dietary Habits and Stomach Cancer Risk in the JACC Study
- Visual Display Terminal Work and Sick Building Syndrome : The Role of Psychosocial Distress in the Relationship
- Serum Pepsinogen Values and Helicobacter pylori Status among Control Subjects of a Nested Case-Control Study in the JACC study
- Serum Levels of Insulin-like Growth Factor I, II, and Binding Protein 3, Transforming Growth Factor β-1, Soluble Fas Ligand and Superoxide Dismutase Activity in Stomach Cancer Cases and Their Controls in the JACC Study
- Cigarette Smoking and Mortality due to Stomach Cancer : Findings from the JACC Study
- Green Tea and Stomach Cancer : A Short Review of Prospective Studies
- Mortality and Incidence Rates of Stomach Cancer in the JACC Study
- Walking Exercise and Its Relationship to Serum Lipids in Japanese
- Association Between Self-Reported Stressful Feeling by SACL and Mortality in a Japanese Community
- Reproducibility and Validity of a Self-administered Food Frequency Questionnaire Used in the JACC Study
- Designing Scaffolds of Peptides for Phage Display Libraries
- An International Comparison of the Involvement of Epidemiology in Most Frequently Cited Publications in the Field of Clinical Medicine
- Parental Obesity, Lifestyle Factors and Obesity in Preschool Children : Results of the Toyama Birth Cohort Study
- Characteristic Lifestyles in 6-year-old Children with Obese Parents : Results of the Toyama Birth Cohort Study
- An International Comparison of the Involvement of Epidemiology in Most Frequently Cited Publications in the Field of Clinical Medicine
- Parental Obesity, Lifestyle Factors and Obesity in Preschool Children : Results of the Toyama Birth Cohort Study
- Hepatitis B Surface Antigen and Antibody among Chronic Hemodialysis Patients in Fukuoka, Japan : A High Risk for Becoming Hepatitis B Virus Carriers